5-Amino-1MQ
5-Amino-1-Methylquinolinium
The NNMT inhibitor that targets stubborn fat at the cellular level
5-Amino-1MQ is a small molecule that inhibits NNMT, an enzyme linked to fat cell expansion and metabolic dysfunction. It represents a novel approach to fat loss that works at the epigenetic level.
Admin routes
Oral
Popularity
Medium
Side effects
Generally mild
AU vendors
0 rated
✓Key benefits
📈What to expect
Subtle metabolic shift; no dramatic initial effects
Fat mobilisation begins; improved energy levels
Measurable fat loss, particularly in stubborn areas
Cumulative body composition improvements
Based on community reports and published research. Individual results vary significantly.
💊Dosing protocols
Fat loss
50–100 mg
Once or twice daily (oral)
8–12 week cycles
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Preclinical - animal studies, no human trials published
Overview
5-Amino-1MQ is not technically a peptide - it's a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor. However, it is widely sold and discussed in the peptide community. NNMT is an enzyme that is overexpressed in fat tissue, particularly visceral and 'stubborn' fat. High NNMT activity is associated with obesity, metabolic syndrome, and resistance to fat loss. By inhibiting NNMT, 5-Amino-1MQ reduces fat cell size, promotes fat oxidation, and may improve metabolic function. It was developed by researchers at the University of Texas and has shown promising results in animal models.
⚙️How it works
NNMT normally methylates nicotinamide (a form of vitamin B3), consuming SAM (S-adenosylmethionine) in the process. High NNMT activity in fat cells depletes SAM, which reduces the cell's ability to perform methylation-dependent processes including lipolysis regulation. By inhibiting NNMT, 5-Amino-1MQ restores SAM levels in fat cells, promoting fat breakdown and reducing fat storage. It also appears to increase NAD+ availability (since less nicotinamide is being methylated away), creating a link to the NAD+/sirtuin longevity pathway.
⚡Side effects
📅Research history
NNMT identified as obesity target in landmark Nature paper
University of Texas develops selective NNMT inhibitors including 5-Amino-1MQ
Rapidly adopted in peptide community for stubborn fat loss
Further research on metabolic syndrome applications
A novel mechanism
Most fat loss compounds work through appetite suppression (GLP-1 agonists), metabolic rate increase (thyroid hormones), or fat oxidation (GH, AOD-9604). 5-Amino-1MQ takes a different approach - it targets the epigenetic machinery within fat cells themselves. By inhibiting NNMT, it changes how fat cells regulate their own metabolism. This makes it potentially useful for 'stubborn' fat deposits that resist traditional approaches. However, it's important to note that all data comes from animal studies - no human clinical trials have been published.
References
- [1]Neelakantan H, et al. "Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice." Biochemical Pharmacology, 2018.
- [2]Kraus D, et al. "Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity." Nature, 2014.
Frequently asked questions
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Open CalculatorDisclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Australian regulations classify many peptides as Schedule 4 (prescription-only) substances. Check current TGA guidelines before purchasing.