Selank
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro)
The anxiolytic peptide that enhances cognition without sedation
Selank is a synthetic peptide analogue of the immunomodulatory protein tuftsin, developed in Russia alongside Semax. It has been approved in Russia since 2009 for anxiety and cognitive enhancement.
Admin routes
Intranasal
Popularity
Medium
Side effects
Generally mild
AU vendors
2 rated
✓Key benefits
📈What to expect
Reduced anxiety within hours; calming without sedation
Stabilised mood; improved stress resilience
Enhanced cognitive function and focus
Sustained anxiolytic and immune-modulating effects
Based on community reports and published research. Individual results vary significantly.
💊Dosing protocols
Anxiety relief
250–500 mcg
2–3 times daily (intranasal)
14-day courses
Cognitive stack (with Semax)
250–300 mcg Selank + 200–400 mcg Semax
1–2 times daily (intranasal)
10–14 day courses
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Approved pharmaceutical in Russia since 2009
Overview
Selank is a heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences - the same lab that created Semax. It is a synthetic analogue of the naturally occurring immunomodulatory peptide tuftsin, with an added Pro-Gly-Pro tripeptide for stability. Approved as a pharmaceutical in Russia since 2009, it is prescribed for generalised anxiety disorder (GAD) and as a nootropic. Unlike benzodiazepines, Selank produces anxiolytic effects without sedation, cognitive impairment, or dependency. It is commonly stacked with Semax for combined anti-anxiety and cognitive enhancement effects.
⚙️How it works
Selank modulates GABA-A receptor sensitivity, enhancing inhibitory neurotransmission without directly binding the benzodiazepine site. It also increases BDNF expression (similar to Semax), modulates serotonin metabolism, and has demonstrated immunomodulatory effects through its tuftsin-derived structure. Unlike traditional anxiolytics, it does not impair memory or motor function - in fact, it enhances them. It also appears to stabilise enkephalin levels in the blood, which may contribute to its mood-stabilising effects.
⚡Side effects
📅Research history
Developed at the Institute of Molecular Genetics, Moscow
Approved in Russia as an anxiolytic nasal spray
Popularized globally through nootropic and peptide communities
Studies on immune-modulating properties expand understanding
Growing interest as a non-addictive anxiolytic alternative
🏪Rated vendors (Australia)
View all →LotusLabs
Australia · 99%+ (HPLC and mass spectrometry) purity · Same-day dispatch, 2–3 days delivery
lotuslabs.com.au ↗Vendor ratings are based on community feedback and are not endorsements. Always verify third-party certificates of analysis (CoA) and check current Australian regulations before purchasing.
Selank vs benzodiazepines
Selank's most compelling advantage over traditional anxiolytics is its clean side effect profile. Benzodiazepines (Valium, Xanax) work but cause sedation, impair memory, build tolerance, and carry dependency risk. Selank reduces anxiety while simultaneously improving cognitive function - the opposite of the benzo trade-off. Russian clinical studies showed comparable anxiolytic efficacy to phenazepam (a potent benzo) without any of the associated cognitive impairment. This makes it particularly attractive for people who need anxiety relief while maintaining cognitive performance.
References
- [1]Zozulya AA, et al. "Selank (TP-7) peptide anxiolytic." Bulletin of Experimental Biology and Medicine, 2001.
- [2]Kozlovskii II, et al. "The anxiolytic-like properties of Selank." Experimental and Clinical Psychopharmacology, 2003.
- [3]Ershov FI, et al. "Antiviral activity of immunomodulator Selank in experimental influenza infection." Bulletin of Experimental Biology, 2009.
Frequently asked questions
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Open CalculatorDisclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Australian regulations classify many peptides as Schedule 4 (prescription-only) substances. Check current TGA guidelines before purchasing.