Sermorelin
Growth Hormone-Releasing Hormone (1-29)
The original GH-releasing peptide - FDA-approved since 1997
Sermorelin is a synthetic analog of GHRH that stimulates natural growth hormone production from the pituitary. One of the few peptides with FDA approval history.
Admin routes
Subcutaneous
Popularity
High
Side effects
Generally mild
AU vendors
0 rated
✓Key benefits
📈What to expect
Improved sleep quality, particularly deep sleep
Increased energy; improved recovery from exercise
Subtle body composition changes begin
Full GH benefits: skin, body composition, energy, sleep
Based on community reports and published research. Individual results vary significantly.
💊Dosing protocols
Anti-aging / GH optimisation
200–300 mcg
Once daily before bed
3–6 months
Body composition
300 mcg
Once daily before bed
3–6 months
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Phase 3 complete - previously FDA-approved (Geref, discontinued 2008)
Overview
Sermorelin is the biologically active fragment (amino acids 1-29) of growth hormone-releasing hormone (GHRH), which is naturally produced by the hypothalamus. It was FDA-approved in 1997 under the brand name Geref for diagnosing and treating growth hormone deficiency in children. Although the brand product was discontinued in 2008, compounded sermorelin remains one of the most prescribed peptides in anti-aging medicine.
⚙️How it works
Binds to GHRH receptors on the anterior pituitary gland, stimulating the synthesis and secretion of growth hormone. Unlike exogenous HGH, sermorelin maintains the body's natural feedback loops - the pituitary still regulates GH release through somatostatin, preventing supraphysiological spikes. This makes it a 'gentler' approach to GH optimization.
⚡Side effects
📅Research history
GHRH structure identified; sermorelin synthesised as the active 1-29 fragment
FDA approves Geref (sermorelin) for paediatric growth hormone deficiency
Geref discontinued by manufacturer for commercial reasons
Compounded sermorelin becomes staple of anti-aging clinics
Remains one of the most prescribed GH-stimulating peptides globally
Sermorelin vs HGH
The key advantage of sermorelin over direct HGH injection is that it works through the body's natural regulatory system. HGH injections bypass the pituitary entirely, which can lead to desensitisation and dependency. Sermorelin stimulates your own pituitary to produce GH, maintaining normal feedback mechanisms. However, if the pituitary is significantly damaged or aged, sermorelin may be less effective.
Why was Geref discontinued?
Sermorelin (Geref) was not discontinued due to safety concerns. The manufacturer (EMD Serono) stopped production for commercial reasons - the product had limited market share due to the availability of direct HGH. Compounding pharmacies continue to produce sermorelin, and it remains one of the most commonly prescribed peptides in longevity clinics.
References
- [1]Prakash A, Goa KL. 'Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.' BioDrugs, 1999.
- [2]Walker RF. 'Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?' Clinical Interventions in Aging, 2006.
Frequently asked questions
Related peptides
Need to calculate your dose?
Use our free reconstitution calculator to work out syringe units for Sermorelin.
Open CalculatorDisclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Australian regulations classify many peptides as Schedule 4 (prescription-only) substances. Check current TGA guidelines before purchasing.