Immune Support

Thymogen

Thymogen (Glutamyl-Tryptophan)

The simplest thymic peptide: just two amino acids

Thymogen is a synthetic dipeptide (Glu-Trp) developed in Russia as an immune modulator. Despite being only two amino acids, it has demonstrated T-cell modulatory activity in Russian clinical studies.

Thy
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Admin routes

Intranasal, Intramuscular

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Popularity

Niche

Side effects

Generally mild

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AU vendors

0 rated

Key benefits

1Registered pharmaceutical in Russia for immune deficiency
2Intranasal formulation available for non-invasive use
3Normalises CD4/CD8 ratio in immunocompromised patients
4Minimal reported side effects due to simple dipeptide structure

📈What to expect

1
Day 3-5

Possible improvement in immune markers

2
Day 5-10

Normalisation of T-cell subsets reported in Russian literature

Based on community reports and published research. Individual results vary significantly.

💊Dosing protocols

Immune support (Russian protocol)

Dose

100 mcg

Frequency

Intranasal, once daily

Duration

5-10 day courses, repeated as needed

Immune restoration (injectable)

Dose

100 mcg

Frequency

Intramuscular, once daily

Duration

3-10 day course

Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.

Research status|Registered pharmaceutical in Russia; limited Western data

Overview

Thymogen was developed at the Institute of Bioregulation and Gerontology in Saint Petersburg as part of the Khavinson peptide bioregulator program. It is one of the simplest bioactive peptides known: just two amino acids (glutamic acid and tryptophan). In Russian medicine, it is registered as a pharmaceutical for immune deficiency states, chronic infections, and post-surgical immune recovery. It is available as both injectable and intranasal formulations. Western peer-reviewed data is limited, but Russian clinical studies report effects on T-cell differentiation and immune function restoration.

⚙️How it works

The exact mechanism is not fully characterised in Western literature. Russian researchers propose that the Glu-Trp sequence interacts with thymic epithelial cells to promote T-cell maturation and differentiation. It is reported to normalise the CD4/CD8 ratio, enhance thymic output of naive T-cells, and modulate cytokine profiles toward balanced Th1/Th2 responses.

Side effects

Mild nasal irritation (intranasal route)
mildCommon

📅Research history

1990s

Thymogen developed at the Saint Petersburg Institute of Bioregulation

2003

Khavinson publishes on thymic peptides and longevity

References

  1. [1]Khavinson VK, Morozov VG. 'Peptides of pineal gland and thymus prolong human life.' Neuroendocrinology Letters, 2003.

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Disclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Australian regulations classify many peptides as Schedule 4 (prescription-only) substances. Check current TGA guidelines before purchasing.