Ipamorelin
Ipamorelin Acetate
The cleanest growth hormone secretagogue available
Ipamorelin is a selective GH secretagogue that stimulates growth hormone release without affecting cortisol, prolactin, or appetite. Often considered the safest GH peptide.
Admin routes
Subcutaneous
Popularity
High
Side effects
Generally mild
AU vendors
0 rated
✓Key benefits
📈What to expect
Improved sleep quality; more vivid dreams
Better recovery from workouts; subtle fat loss
Body composition improvements; increased lean mass
Full GH optimisation; skin quality and energy improvements
Based on community reports and published research. Individual results vary significantly.
💊Dosing protocols
GH optimisation (standalone)
200–300 mcg
Once or twice daily
8–12 weeks
Combined with CJC-1295
100–200 mcg
Once daily before bed
8–12 weeks
Dosing information is sourced from published research and community protocols. This is not a recommendation. Consult a healthcare professional.
Research status|Phase 2 clinical data available - extensive research
Overview
Ipamorelin is a pentapeptide growth hormone secretagogue that selectively stimulates GH release from the pituitary gland. Unlike other secretagogues (GHRP-6, GHRP-2), ipamorelin does not significantly increase cortisol, ACTH, prolactin, or appetite - making it the most selective and 'cleanest' GH-releasing peptide available. It is most commonly used in combination with CJC-1295 but is also effective as a standalone.
⚙️How it works
Binds to ghrelin receptors (GHS-R1a) on pituitary somatotrophs, triggering growth hormone release. Unlike GHRP-6, it does not strongly activate ghrelin's appetite-stimulating effects. The GH release follows natural pulsatile patterns, and the pituitary's somatostatin feedback remains intact - preventing supraphysiological GH levels.
⚡Side effects
📅Research history
First described as 'the first selective growth hormone secretagogue' by Raun et al.
Clinical studies confirm minimal side effect profile
Shown to not increase cortisol, ACTH, or prolactin at therapeutic doses
Becomes most popular GH peptide in anti-aging clinics
Gold standard for clean GH optimisation
Ipamorelin vs GHRP-6 vs GHRP-2
GHRP-6 was one of the first GH secretagogues studied but causes intense hunger and raises cortisol and prolactin. GHRP-2 is more potent but still elevates cortisol. Ipamorelin offers GH release without these unwanted effects - the trade-off is slightly lower peak GH levels per dose. For most users seeking anti-aging or body composition benefits, ipamorelin's cleaner profile makes it the preferred choice.
References
- [1]Raun K, et al. 'Ipamorelin, the first selective growth hormone secretagogue.' European Journal of Endocrinology, 1998.
- [2]Johansen PB, et al. 'Ipamorelin: a new growth-hormone-releasing peptide.' Journal of Endocrinology, 1999.
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Open CalculatorDisclaimer: This guide is for educational and informational purposes only. It is not medical advice. The dosing protocols listed are sourced from published research and community reports and do not constitute a recommendation. Always consult a qualified healthcare professional before using any peptide. Australian regulations classify many peptides as Schedule 4 (prescription-only) substances. Check current TGA guidelines before purchasing.